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Current Projects in the Lab for Motivation in Psychiatry

ADOLESCENT BRAIN DEVELOPMENT, MEMORY, AND MOTIVATION

The main purpose of this study is to understand how brain structure and function relate to behaviors, motivations, and thoughts, and how these change during adolescence and young adulthood. Brain structure and activity can be measured using a non-invasive technique called magnetic resonance imaging (MRI). Functional MRI (fMRI) tells us the pattern and distribution of blood flow in the brain, which change when brain activity changes.


About 140 people ages 16-26 will participate in this study at the University of Pennsylvania. This study involves 4 visits in total over the course of about 2 years. The first two visits of the study will be completed within one month of each other. The second two visits will be completed about two years later.

 

Dr. Wolf is also a Collaborating Investigator on multiple projects, including:

A TRANSLATIONAL AND NEUROCOMPUTATIONAL EVALUATION OF A D1R PARTIAL AGONIST FOR SCHIZOPHRENIA (PENN PI RAQUEL GUR)

This multi-site study will test in early-stage schizophrenia the dose-related effects of a potentially pro-cognitive dopamine D1R/D5R partial agonist, PF-06412562, on neuroimaging biomarkers based on translational and computational neuroscience understanding of the role of D1R/D5Rs in cortical systems.

MAPPING HETEROGENEITY OF NEUROANATOMICAL IMAGING SIGNATURES OF PSYCHOSIS VIA PATTERN ANALYSIS (PI CHRISTOS DAVATZIKOS)

This project aims to use advanced pattern analysis and machine learning methods to structural MRI data, in order to elucidate patterns of neuroanatomical change in psychosis, and use those to derive diagnostic and predictive indices on an individual patient basis.

LONGITUDINAL MAPPING OF NETWORK DEVELOPMENT UNDERLYING EXECUTIVE DYSFUNCTION IN ADOLESCENCE (PIS TED SATTERTHWAITE & DANI BASSETT)

This project applies multi-level image analysis to examine the neurodevelopmental substrates of executive dysfunction across psychiatric disorders in adolescence.

CREATING AN ADAPTIVE SCREENING TOOL FOR DETECTING NEUROCOGNITIVE DEFICITS AND PSYCHOPATHOLOGY ACROSS THE LIFESPAN (PI RUBEN GUR)

This project applies item response theory to develop a time-efficient adaptive tool for assessing broad neurocognitive functioning and psychopathology.

 

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